New HIV peptide-based immunoassay resolves vaccine-induced seropositivity in HIV vaccine (Phase III) trial participants
نویسندگان
چکیده
منابع مشابه
Vaccine-induced HIV seropositivity/reactivity in noninfected HIV vaccine recipients.
CONTEXT Induction of protective anti-human immunodeficiency virus (HIV) immune responses is the goal of an HIV vaccine. However, this may cause a reactive result in routine HIV testing in the absence of HIV infection. OBJECTIVE To evaluate the frequency of vaccine-induced seropositivity/reactivity (VISP) in HIV vaccine trial participants. DESIGN, SETTING, AND PARTICIPANTS Three common US Fo...
متن کاملPerformance of a redesigned HIV Selectest enzyme-linked immunosorbent assay optimized to minimize vaccine-induced seropositivity in HIV vaccine trial participants.
Vaccine-induced seropositivity (VISP) or seroreactivity (VISR), defined as the reaction of antibodies elicited by HIV vaccines with antigens used in HIV diagnostic immunoassays, can result in reactive assay results for vaccinated but uninfected individuals, with subsequent misclassification of their infection status. The eventual licensure of a vaccine will magnify this issue and calls for the ...
متن کاملSeropositivity among Uninfected HIV Vaccine Recipients
Marta-Louise Ackers, Bharat Parekh, Thomas G. Evans, Phillip Berman, Susan Phillips, Mary Allen, and J. Steven McDougal HIV Vaccine Section, Epidemiology Branch, Division of HIV/AIDS Prevention–Surveillance and Epidemiology, National Center for HIV, STD, and TB Prevention, and HIV Immunology and Diagnostics Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectiou...
متن کاملVaccine-induced HIV seropositivity: a problem on the rise.
BACKGROUND Vaccine-induced antibodies to envelope proteins frequently cause HIV seroconversion in uninfected recipients of HIV vaccine candidates and may thus have an impact on the vaccinee's ability to donate blood or acquire a life insurance policy. OBJECTIVE To determine the occurrence of positive test results when commonly used HIV immunoassays are used to screen sera of HIV-uninfected vo...
متن کاملDesigning Peptide-Based HIV Vaccine for Chinese
CD4+ T cells are central to the induction and maintenance of CD8+ T cell and antibody-producing B cell responses, and the latter are essential for the protection against disease in subjects with HIV infection. How to elicit HIV-specific CD4+ T cell responses in a given population using vaccines is one of the major areas of current HIV vaccine research. To design vaccine that targets specificall...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2012
ISSN: 1742-4690
DOI: 10.1186/1742-4690-9-s2-p120